Stat1 and cancer
WebNov 29, 2024 · Background: Signal transducer and activator of transcription (STAT) 1 is an important transcription factor and has been reported to be a tumor suppressor in many types of cancer. However, another STAT family member, STAT3, is considered to be an oncogene. The cross-talk between STAT1 and STAT3 in cancer has not been fully … WebApr 12, 2024 · Hormone receptor-positive and HER2-negative (HR+/HER2−; luminal A) tumors are prevalent in breast cancer. Our past studies demonstrated that “TME Stimulation” (estrogen + TNFα + EGF, representing three arms of the tumor microenvironment, TME) has enriched metastasis-forming cancer stem cells (CSCs) in HR+/HER2− human breast …
Stat1 and cancer
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WebFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that lanes 1‑3 of the EMSA results shown in Fig. 6 on p. 1278 were strikingly similar to data that had already appeared in a different form in the following publication by different authors at diffe … WebNov 26, 2024 · Simultaneously, in human tumors, such as breast cancer and Wilms tumor, the expression of STAT1 is associated with a better prognosis. 84 However, some studies …
WebOct 31, 2016 · Altogether, these data indicate that IL-27 and IFN-γ display a broad overlap of functions in human cancer cells, which are related to STAT1 pathway activation by both cytokines. Therefore, the effects of STAT1 seem to prevail over those of STAT3 signaling, which is also activated by IL-27 and may be involved in the regulation of a smaller set ... WebApr 13, 2024 · The role of STAT1 signaling in TME has been previously suggested in Renca monoclonal cancer model, where a high expression of inflammatory gene signature driven by STAT1 signaling in TIME is ...
Web2 days ago · The role of microRNAs (miRNAs) in Mycobacterium fortuitum pathogenesis is not well illustrated. Using zebrafish kidney macrophages (ZFKM) we observed that M. fortuitum triggers miR-155 expression, and the TLR-2/NF-κB axis plays a key role in initiating the process. We report that mir-155 activates the pro-inflammatory Stat1/TBX21 … WebThe cross-talk between STAT1 and STAT3 in cancer has not been fully demonstrated. Materials and methods: Esophageal squamous cell carcinoma (ESCC) was used as a …
WebMay 8, 2024 · The tumor-suppressive role of STAT1 is driven by findings that the reconstitution of STAT1 in STAT1-deficient murine fibrosarcoma cells significantly suppressed tumorigenicity and metastasis in nude mice. 53 The high expression of STAT1 is reported to have a good prognosis compared with the low or negative expression of …
WebWe, the Editors and Publisher of the journal Cell Cycle, have retracted the following article:. Yuguang Yang, Jin Wu, Hongfeng Zhou, Wenming Liu, Jincai Wang and Qingyuan Zhang. STAT1-induced upregulation of lncRNA LINC01123 predicts poor prognosis and promotes the progression of endometrial cancer through miR-516b/KIF4A. infant pco2 highWeb2 days ago · Galectin-3 is a galactoside-binding protein that is commonly overexpressed in many epithelial cancers. It is increasingly recognized as a multi-functional, multi-mode promoter in cancer ... infant party shoesWebMay 8, 2024 · This study has shown that STAT1 is identified to have prognostic value as STAT1 is a potential marker of prognosis in patients with solid cancer. Highly expressed … infant patent shoesWebSTAT1 is required for signaling of all the interferons (α, β, γ, ω, λ). Complete (recessive) loss of activity of STAT1 leads to early fatal infections with mycobacteria and viruses. … infant peanut allergy managementWebAug 1, 2024 · The specific role of STAT1 in cancer remains ambiguous, as it is known to exhibit both tumor suppressor as well as oncogenic properties in a context-dependent manner [38].Several types of cancers ... infant pcamWebNational Center for Biotechnology Information infant patchworkWebNov 10, 2024 · In real-world samples of patients with mCRC, we found that higher STAT1 expression in tumor cells was strongly indicative of a highly immunogenic microenvironment, with significantly higher expression levels of MHC class I and PD-L1, not only on tumor cells but also on non-tumor cells. infant pdl